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Products EP3 Receptor Polyclonal Antibody
| Catalogue number: | 101760 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human EP3 receptor amino acids 308-327 (NQTSVEHCKTHTEKQKECNF){1900,3180} |
| P type: | Antibodies|Eicosanoids |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4. As a result of splice variation, the EP3 receptor can be expressed as multiple isoforms that differ in the length and sequence of their C-terminal tails. The signal transduction mechanism varies depending on the isoform being expressed, implicating the importance of the C-terminal region of the receptor for coupling to G-proteins. The EP3 receptor is expressed in a variety of tissues with highest levels in kidney, pancreas, and uterus. |
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