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Epidermal Growth Factor Receptor (erbB, EGFR, EC=2.7.10.1, ERBB, ERBB1, MENA)

Epidermal Growth Factor Receptor (erbB, EGFR, EC=2.7.10.1, ERBB, ERBB1, MENA)

Cat no: E3375-01L

Supplier: United States Biological
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EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), emphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas. Cellular Localization: Cell Membrane and Secreted Positive Control: A431 cells. Applications: Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3375-01L
Reactivities: Human, Canine
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation
Size: 500ul
Form: 10mM PBS, pH7.4, 0.2%BSA
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
Alternative names: EC=2.7.10.1, ERBB, ERBB1, MENA
References: 1. Wikstrand CJ et al. (1995). Cancer Res 55:3140-8. 2. Hartigh JC et al. (1993) Biochim Biophys Acta 1148:249-56. 3. Kawamoto T, et al., (1983) Proc Natl Acad Sci USA 80:1337-41. 4. Sato JD et al. (1983) Mol Biol Med 1:511-29.
Additional info: Species Crossreactivity: Crossreacts with Human and canine. Does not crossreact with Rat or Mouse.

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