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Epidermal Growth Factor Receptor (erbB, EGFR, EC=2.7.10.1, ERBB, ERBB1, MENA)

Cat no: E3375-01T


Supplier: United States Biological
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Cellular Localization: Membrane, cytoplasm Positive Control: Breast carcinoma Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3375-01T
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: As reported
P type: Mab
Isotype: IgG1
Purity: As reported
Alternative names: EC=2.7.10.1, ERBB, ERBB1, MENA
References: 1. Christensen et al., (1998) Danish Med Bull 45(2):121. 2. Niikura et al., (1996) Human Pathol 27(3). 3. Rusch et al., (1996) Ann Thorac Surg 62:798.
Additional info: The epidermal growth factor receptor (EGFR) is a 170kD transmembrane protein consisting of an extracellular EGF-binding domain with ligand-activated tyrosine kinase activity. EGFR is expressed in many normal epithelial tissues, particularly in the basal layers of stratified epithelium and in squamous epithelium. Over expression of EGFR has been observed in many types of neoplasia, as a result of gene amplification and/or increased protein transcription. Species Crossreactivity: This antibody is reactive against human.

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