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Epidermal Growth Factor Receptor (erbB, EGFR), External Domain (Biotin)

Epidermal Growth Factor Receptor (erbB, EGFR), External Domain (Biotin)

Cat no: E3375-14B

Supplier: United States Biological
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The EGFR mediates the initial response of cells to EGF. It has an extracellular region, which binds EGF and an intracellular region, which exhibits tyrosine kinase activity (1). The receptor phosphorylates a number of protein substrates in addition to mediating autophosphorylation of tyrosine residues located near its carboxyl terminus (2,3). Applications: Suitable for use in Immunohistochemistry and Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1ug labels 1x10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3375-14B
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Conjugates: Biotin
Size: 250ug
Form: Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide. Labeled with Biotin.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Berger, S.M., et al., (1987), J. of Pathology, 152:297,2. Downward, J., et al., (1984), Nature, 311:483,3. Gullick, W.J., et al., (1985), EMBP J., 4:2869,4. Gullick, W.J., et al., (1986), Cancer Research, 46:285, 5. Gullick, W.J., et al., (1991), Br. Med. Bulletin, 47:87.
Additional info: Recognizes the extracellular domain of the human epidermal growth factor receptor at ~170kD.

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