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ErbB2 (c-erbB2, HER2, neu Oncoprotein)

ErbB2 (c-erbB2, HER2, neu Oncoprotein)

Cat no: E3451-25J

Supplier: United States Biological
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ErbB2 (also known as Her2 or neu) is a 185kD transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Tyrosine 1248 within the cytoplasmic domain of the receptor is an auto-phosphorylation site that allows binding of Shc and activation of the Ras, Raf, ERK1&2 signaling pathway. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3451-25J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.1% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Alternative names: C-ERBB-2, EC=2.7.10.1, ERBB2, HER-2, HER-2/NEU, NEU, NGL, P185ERBB2, TKR1
Additional info: Species Crossreactivity: This antibody crossreacts with human. In initial tests of lysate from mouse NIH3T3 cells, mouse ErbB2 was not readily detectable. Other species have not been tested.

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