ERK/MAPK (Phospho-Thr202/Tyr204) Cell-Based Phosphorylation/Translocation Assay Kit

Cayman's ERK/MAPK (Phospho-Thr202/Tyr204) Cell-Based Phosphorylation/Translocation Assay provides the tools necessary to study ERK/MAPK phosphorylation and translocation within whole cells. The kit contains a phospho-specific ERK/MAPK (Phospho-Thr202 and Tyr204) primary antibody together with a DylightTM (product of Thermo Scientific) conjugated secondary antibody in a ready-to-use format. Tamoxifen, which has been shown by scientists at Cayman Chemical to cause the translocation of phosphorylated ERK/MAPK (Phospho-Thr202/Tyr204) between the cytoplasm and nuclear compartments, is included as a positive control.

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SPECIFICATIONS

Catalog Number

10010549

Form

1 ea

P Type

Assay Kits|Intracellular Signaling

Weight

0

Storage Temp

-20

Shipping Temp

-20

Additional Info

Extracellular signal-regulated kinases (ERKs) 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase (MAPK) family of cell signalling enzymes controlling cell fates such as embryogenesis, cell differentiation, cell proliferation, and cell death. ERK1/2 are activated via dual phosphorylation on specific tyrosine (Tyr204) and threonine (Thr202) residues by mitogen-activated or extracellular signal-regulated protein kinase kinase (MEK). Cayman's ERK/MAPK (Phospho-Thr202/Tyr204) Phosphorylation/Translocation Cell-Based Assay Kit provides the tools necessary to study ERK/MAPK phosphorylation and translocation within whole cells. The kit contains a phospho-specific ERK/MAPK (Phospho-Thr202 and Tyr204) primary antibody together with a DyLightTM (product of Thermo Fisher Scientific Inc.) conjugated secondary antibody in a ready-to-use format. Tamoxifen, which has been shown by scientists at Cayman Chemical to cause the translocation of phosphorylated ERK/MAPK (Phospho-Thr202/Tyr204) between the cytoplasm and nuclear compartments, is included as a positive control.