Home  >  Products  >  Estrogen Receptor, alpha (ER alpha, ERa, ESRA, DKFZp686N23123, Estradiol Receptor, ESR, Estrogen Receptor 1, ESR 1, ESR1, Major ORF, Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1)
Estrogen Receptor, alpha (ER alpha, ERa, ESRA, DKFZp686N23123, Estradiol Receptor, ESR, Estrogen Receptor 1, ESR 1, ESR1, Major ORF, Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1)

Estrogen Receptor, alpha (ER alpha, ERa, ESRA, DKFZp686N23123, Estradiol Receptor, ESR, Estrogen Receptor 1, ESR 1, ESR1, Major ORF, Nuclear Receptor Subfamily 3 Group A Member 1, NR3A1)

Cat no: E3565-09E

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Estrogen receptor alpha (ER alpha) is a nuclear protein and member of the steroid hormone receptor family. ER alpha possesses both DNA binding and ligand binding domains, and exerts a significant role in activating the transcription of certain genes (1). Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha (2). The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy (3). Applications: Suitable for use Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: E3565-09E
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Hockenbery, D. et al. Nature 348: 334 2. Cleary, M.L. et al. Cell 47: 19 3. Ruvolo, P.P et al. J. Biol. Chem. 276: 23681.kDa
Additional info: Recognizes human ERalpha.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave