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ETV4, CT (Pea-3, ETS Translocation Variant 4, Polyomavirus Enhancer Activator 3 Homolog, Protein PEA3, pea3)

ETV4, CT (Pea-3, ETS Translocation Variant 4, Polyomavirus Enhancer Activator 3 Homolog, Protein PEA3, pea3)

Cat no: E8851-16M

Supplier: United States Biological
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ETS-transcription domain factor pea-3 (pea-3) is a subfamily of ETS- domain proteins that has been implicated in several tumorigenic processes and regulates transcriptional activation. Specificity of DNA binding action by zebrafish pea-3 is virtually identical to activity exhibited by mammalian pea-3, indicating a high level of conservation. Transcriptional activation by zebrafish pea-3 is potentiated by the ERK MAP kinase and protein kinase A pathways. Fibroblast growth factor (fgf) signaling is involved in the control of pea-3 as well. The tight coupling of fgf signaling to pea-3 transcription suggests that pea-3 is a direct readout of fgf activity, and may shed insight on refined patterns in embryonic development. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: E8851-16P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E8851-16M
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Brown, LA et al (1998) Oncogene 17:93-104. 2. Raible, F and Brand, M (2001) Mech. Dev. 107(1-2):105-117.
Additional info: Recognizes zebrafish Pea-3.

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