Home  >  Products  >  Eukaryotic Translation Initiation Factor 2, alpha (Eukaryotic Translation Initiation Factor 2A, eIF2a, eIF-2A, 65 kD Eukaryotic Translation Initiation Factor 2A, CDA02, MSTP004, MST089, MSTP089)
Eukaryotic Translation Initiation Factor 2, alpha (Eukaryotic Translation Initiation Factor 2A, eIF2a, eIF-2A, 65 kD Eukaryotic Translation Initiation Factor 2A, CDA02, MSTP004, MST089, MSTP089)

Eukaryotic Translation Initiation Factor 2, alpha (Eukaryotic Translation Initiation Factor 2A, eIF2a, eIF-2A, 65 kD Eukaryotic Translation Initiation Factor 2A, CDA02, MSTP004, MST089, MSTP089)

Cat no: E8949-01G

Supplier: United States Biological
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Eukaryotic initiation factor 2A (eIF2a) is a 65kD protein that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low [Mg2+]. eIF2a binds initiator tRNA in a GTP-independent manner, but require the presence of the small ribosomal subunit and the trinucleotide start codon, AUG. Phosphorylation of the protein terminates global protein translation and induces apoptosis. human eIF2a gene is localized on chromosome 3q25.1. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochestry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: K562 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E8949-01G
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Eukaryotic Translation Initiation Factor 2A, 65kDa
References: 1. Wendy, Zoll. et al. J. Biol. Chem. 277:37079-37087 (2002). 2. Chang, RCC. et al. Neuroreport. 13:2429-2432 (2002).
Additional info: Recognizes human eIF2a. Species crossreactivity: mouse and rat.

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