Eukaryotic Translation Initiation Factor 4B (eIF4B), phosphorylated (Ser504)

Cat no: E8949-39B

Supplier: United States Biological

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Eukaryotic protein synthesis initiation factor 4B eIF-4B) is an 80,000 dalton polypeptide which is essential for the binding of mRNA to ribosomes. The amino-terminal domain of eIF-4B contains a consensus RNA binding domain present in a number of other RNA binding proteins (1). It contains a ribonucleoprotein consensus sequence (RNP-CS)/RNA recognition motif (RRM). Deletions which remove this region abolish the ability of eIF-4B to cooperate with eIF-4A in RNA binding and the ability to stimulate the helicase activity of eIF-4A. Results indicate that the carboxy-terminal RNA-binding region of eIF-4B is essential for eIF-4B function and is distinct from the RNP-CS/RRM (2). eIF4F binds to the mRNA cap structure and, in combination with eIF4B, is believed to unwind the secondary structure in the 5

Catalogue number:	E8949-39B
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
References:	1. Milburn SC, et al. EMBO J, 9(9):2783-90, 1990. 2. Methot N, et al. Mol Cell Biol 14(4):2307-16, 1994 3. Methot N, et al. Mol Cell Biol 16(10):5328-34, 1996.
Additional info:	Recognizes human eIF4B phosphorylated at serine 504.

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Eukaryotic Translation Initiation Factor 4B (eIF4B), phosphorylated (Ser504)

Cat no: E8949-39B

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