Home  >  Products  >  Exonuclease I (Exonuclease-I, ExoI, Exonuclease 1, Exonuclease-1, Exo1, HEX1, hExo1, hExoI, Rad2 Nuclease Family Member Homolog of S. cerevisiae Exonuclease 1)
Exonuclease I (Exonuclease-I, ExoI, Exonuclease 1, Exonuclease-1, Exo1, HEX1, hExo1, hExoI, Rad2 Nuclease Family Member Homolog of S. cerevisiae Exonuclease 1)

Exonuclease I (Exonuclease-I, ExoI, Exonuclease 1, Exonuclease-1, Exo1, HEX1, hExo1, hExoI, Rad2 Nuclease Family Member Homolog of S. cerevisiae Exonuclease 1)

Cat no: E9007-85D

Supplier: United States Biological
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This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq] Epitope: C-HRNYSPRPESGT Theoretical Molecular Weight: 89.1kD Applications: Suitable for use in Peptide ELISA and Western Blot. Other applications not tested. Recommended Dilution: Peptide ELISA: Antibody detection limit dilution 1:64,000 Western Blot: 0.2-0.5ug/ml; Approx 90kDa band observed in lysates in cell lines HEK293 and A549 (calculated MW of 89.1kDa according to NP_003677.3). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E9007-85D
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Kim JC, Roh SA, Yoon YS, et al. MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria. Cancer Genet Cytogenet. 2007 Jul 15;176(2):172-4. No abstract available. PMID: 17656264
Additional info: Recognizes human Exonuclease 1. Expected to recognize all three reported isoforms (NP_003677.3; NP_006018.3 and NP_569082.1).

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