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Ezrin (Cytovillin, Villin-2, p81, EZR, VIL2)

Ezrin (Cytovillin, Villin-2, p81, EZR, VIL2)

Cat no: E9100-25E

Supplier: United States Biological
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Ezrin is a member of the ERM family (ezrin, radixin, moesin) of proteins that link the cell membrane to the actin cytoskeleton and that are involved in cytoskeletal organization, cell motility and morphogenesis. The protein (586aa) consists of three domains: a membrane-binding aminoterminal domain, an extended alpha-helical domain, and a carboxyterminal domain that has an actin-binding site. Aberrantly high ezrin protein expression has been detected in the stromal cells of hemangioblastoma. Moreover, a high ezrin expression level is associated with immortalization and the increased proliferation rate of cells in vitro. It appears to play a role in the progression of tumors, such as the metastasis of osteosarcoma. Human Ezrin gene is localized to the end of the long arm of chromosome 6 (6q22-q27). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Placenta lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E9100-25E
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Stanasila L, Abuin L, Diviani D, Cotecchia S. Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. J Biol Chem. 2006 Feb 17;281(7):4354-63. Epub 2005 Dec 13. PMID: 16352594
Additional info: Recognizes human Ezrin. Species sequence homology: canine.

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