FABP3 Monoclonal Antibody (Clone CC68)

Antigen: synthetic peptide from human FABP3 amino acids 44-55 . Host: mouse . Cross Reactivity:(+) human and rat FABP3, (-) mouse FABP3, other species not tested . Application(s): WB (1:200 dilution); other applications not tested

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SPECIFICATIONS

Catalog Number

10233

Applications

WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

synthetic peptide from human FABP3 amino acids 44-55

Isotype

IgG2b

Storage Temp

-20

Shipping Temp

-20

Additional Info

Fatty acid binding protein 3 (FABP3) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids. Members of this protein family exhibit high affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated. Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation. FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP3 is composed of ten antiparallel .beta. strands that form a barrel and is the most widely distributed FABP. It is found in heart, skeletal and smooth muscle, mammary epithelial cells, aorta, distal tubules of the kidney, lung, brain, placenta, and ovary. FABP3 is a potential biomarker for myocardial injury, especially for early detection of acute myocardial infarction (AMI).