Factor H (Complement Factor H, Beta 1H)

Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop.\n\nMutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.\n\nApplications: \nSuitable for use in Radial Immunodiffusion, Double Diffusion, Immunoelectrophoresis. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add glycerol (40-50%)aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F0010

Size

1ml

Hosts

Sheep

Reactivities

Hum, Mouse, Rat, Can, Fel, GP

Form

Liquid in GBS, pH 7.4 0.1% sodium azide, 0.1% EACA, 0.01% Benzamidine, 1mM EDTA.

P Type

Pab

Purity

Highly purified and sterile-filtered.

Isotype

IgG

Additional Info

Single arc when tested by IEP and 2D-IEP against human plasma. Identity is confirmed by double diffusion (Ouchterlony) against human plasma and a known anti-human Factor H. The crossreactivity of this product against the sera of the species listed below has been assessed by double diffusion using 10ul of antisera against 10ul of species sera.\nSpecies crossreactivity: feline, canine, guinea pig, equine, human, mouse, rat. Does not react with chicken, bovine, porcine, rabbit, or goat.