FADD, ID (Fas (tnfrsf6)-associated via Death Domain (fadd), mRNA)

Fas [tnfrsf6]-associated death domain (FADD) is involved in the extrinsic apoptosis pathway within zebrafish. In one study, inhibition of FADD during ectopic expression of FasL and Apo2L/TRAIL homologs in zebrafish demonstrated blocking of ligand induced apoptosis. Within humans, FADD is associated the proximal signal transduction of Fas. FADD has been implicated, along with FGF3, in human craniofacial disease. Haploinsufficiency of both FGF3 and FADD were identified as the likely causes of otodental syndrome and ocular coloboma. Spatiotemporal in situ hybridization in zebrafish embryos revealed that FADD is expressed during eye development.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5000-1:20,000\nWestern Blot: 1:500-1:1000\nOptimal dilutions to be determined by the researcher.\n\nControl Peptide: F0019-52P\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

F0019-52L

Size

250ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

ZF/Fish

Form

Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Eimon, PM et al (2006) Cell Death Differ. 13(10):1619-1630. 2. Chinnaiyan, AM et al (1995) Cell 81:505-512. 3. Gregory-Evans, CY et al (2007) Hum. Mol. Genet. 16(20):3482-3493.

Additional Info

Recognizes zebrafish FADD.