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FADD, ID (Fas (tnfrsf6)-associated via Death Domain (fadd), mRNA)

FADD, ID (Fas (tnfrsf6)-associated via Death Domain (fadd), mRNA)

Cat no: F0019-52L

Supplier: United States Biological
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Fas [tnfrsf6]-associated death domain (FADD) is involved in the extrinsic apoptosis pathway within zebrafish. In one study, inhibition of FADD during ectopic expression of FasL and Apo2L/TRAIL homologs in zebrafish demonstrated blocking of ligand induced apoptosis. Within humans, FADD is associated the proximal signal transduction of Fas. FADD has been implicated, along with FGF3, in human craniofacial disease. Haploinsufficiency of both FGF3 and FADD were identified as the likely causes of otodental syndrome and ocular coloboma. Spatiotemporal in situ hybridization in zebrafish embryos revealed that FADD is expressed during eye development. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: F0019-52P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F0019-52L
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Eimon, PM et al (2006) Cell Death Differ. 13(10):1619-1630. 2. Chinnaiyan, AM et al (1995) Cell 81:505-512. 3. Gregory-Evans, CY et al (2007) Hum. Mol. Genet. 16(20):3482-3493.
Additional info: Recognizes zebrafish FADD.

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