Home  >  Products  >  FANCJ (FANCJ protein, BACH 1, BACH1 BRIP1, BRIP 1, BRAC 1 Associated C Terminal Helicase 1, BRCA 1 Interacting Protein 1)
FANCJ (FANCJ protein, BACH 1, BACH1 BRIP1, BRIP 1, BRAC 1 Associated C Terminal Helicase 1, BRCA 1 Interacting Protein 1)

FANCJ (FANCJ protein, BACH 1, BACH1 BRIP1, BRIP 1, BRAC 1 Associated C Terminal Helicase 1, BRCA 1 Interacting Protein 1)

Cat no: F0019-58W9B

Supplier: United States Biological
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BRIP1 (also called BACH1) is a helicase that interacts with the BRCT domain of BRCA1 and has a role in BRCA1-dependent DNA repair and checkpoint. BRIP1 has recently been found to be defective in Fanconi anemia complementation group J. BRIP1/FANCJ has a function in the Fanconi anemia pathway that is independent of BRCA1 and downstream of FANCD2 activation. (1-4) Positive Control: HeLa whole and nuclear extracts, Raji whole cell extracts. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F0019-58W9B
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ul
Form: As reported
P type: Mab
Isotype: IgG1,k
Purity: Ascites
Alternative names: FANCJ protein, BACH 1, BACH1 BRIP1, BRIP 1, BRAC 1 Associated C Terminal Helicase 1, BRCA 1 Interacting Protein 1
References: 1. Menichini, P., & Linial, M. SUVi and BACH1: a new subfamily of mammalian helicases? Mut. Res. 487: 67-71, 2001. 2. Ohira, M., et al. Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. Genomics. 47:300-306, 1998. 3. Bridge, W. et al. The BRIP1 helicase function independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. Nature Genetics in press August 2005. 4. Levitis, M. et. al. The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nature Genetics in press August 2005.
Additional info: Specific for human Brip1.

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