The members of the Fanconi anemia complementation group do not share sequence similarity but are related by their assembly into a common nuclear protein complex. A previously defined member, FANCH, is now known to be identical to FANCA.
FANCA is involved in DNA repair and maybe involved in maintainance of normal chromosome stability and inter-strand DNA cross link repair.
Mutations in the FANCA gene are a common cause of Fanconi anemia (FA), a genetically heterogeneous recessive disorder characterized by progressive pancytopenia, susceptibly to malignancies, cytogenetic instability, hypersensitivity to DNA damaging agents and defective DNA repair.
Applications:
Suitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
ELISA: 1:15,000-1:60,000
Western Blot: 1:500-1:3000
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.
Positive Control: Human brain (cerebellum)
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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