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Fanconi anemia D2 (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4)

Fanconi anemia D2 (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4)

Cat no: F0019-58W2

Supplier: United States Biological
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Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F0019-58W2
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: As reported
P type: Mab
Purity: Ascites
Alternative names: FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4
References: 1. Park, S., et al. Oxidative Stress/Damage Induces Multimerization and Interaction of Fanconi Anemia Proteins. The J. Biol. Chem. 279(29): 30053-30059, 2004. [Western Blot, Immunoprecipitation, Human] 2. Nomura, Y. et al. Original Articles: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. Gene Cells. 12: 1111-1122, 2007
Additional info: Species Crossreactivity: This antibody reacts with human FANCD2. This antibody does not react with mouse or hamster. Other species have not been tested.

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