Fanconi anemia D2 (FA4, FACD, FAD, FAD2, FANCD2, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4)

Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F0019-58W2

Size

100ul

Applications

IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

As reported

P Type

Mab

Purity

Ascites

References

1. Park, S., et al. Oxidative Stress/Damage Induces Multimerization and Interaction of Fanconi Anemia Proteins. The J. Biol. Chem. 279(29): 30053-30059, 2004. [Western Blot, Immunoprecipitation, Human]\n2. Nomura, Y. et al. Original Articles: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. Gene Cells. 12: 1111-1122, 2007

Additional Info

Species Crossreactivity: This antibody reacts with human FANCD2. This antibody does not react with mouse or hamster. Other species have not been tested.

Alternative Names

FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia Complementation Group D, Fanconi Pancytopenia Type 4