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FAP (Seprase, 170kD Melanoma Membrane-bound Gelatinase, Fibroblast Activation Protein alpha, Integral Membrane Serine Protease)

FAP (Seprase, 170kD Melanoma Membrane-bound Gelatinase, Fibroblast Activation Protein alpha, Integral Membrane Serine Protease)

Cat no: F4208-57F

Supplier: United States Biological
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Fibroblast Activation Protein alpha is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair and epithelial carcinogenesis. Applications: Suitable for use in ELISA, Immunoprecipitation, and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4208-57F
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG2a,k
Purity: Purified.
References: 1. Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. Denys H, Derycke L, Hendrix A, Westbroek W, Gheldof A, Narine K, Pauwels P, Gespach C, Bracke M, De Wever O.Cancer Lett. 2008 Aug 8;266(2):263-74. 2.Fibroblast activation protein and chronic liver disease. Wang XM, Yao TW, Nadvi NA, Osborne B, McCaughan GW, Gorrell MD.Front Biosci. 2008 Jan 1;13:3168-80.
Additional info: Recognizes human FAP.

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