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Fas (CD95, APO-1, AI196731, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, Apt1, APT1, FASLG receptor, lpr, TNFR6, Tnfrsf6, Tumor necrosis factor receptor superfamily member 6)

Fas (CD95, APO-1, AI196731, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, Apt1, APT1, FASLG receptor, lpr, TNFR6, Tnfrsf6, Tumor necrosis factor receptor superfamily member 6)

Cat no: C2442-32L

Supplier: United States Biological
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Fas/Apo-1/CD95 is a cell surface type-I membrane glycoprotein with an apparent molecular weight of 44kD on SDS-PAGE. Fas is a member of the TNFR family that includes TNFR1, TNFR2, CD27, CD30, and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis in Fas expressing cells. Both Fas and TNF-R contain the 70 amino acids cytoplasmic "death domain" that is responsible for transmitting signal for apoptosis. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilutions: Western Blot: 0.5-4 ug/ml Optimal dilutions to be determined by the researcher. Control Peptide: C2442-32J1:Fas Blocking Peptide Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2442-32L
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 5mM EDTA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Alternative names: CD95, APO-1, AI196731, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, Apt1, APT1, FASLG receptor, lpr, TNFR6, Tnfrsf6, Tumor necrosis factor receptor superfamily member 6
Additional info: Recognizes a 55kD of glycosylated Fas, a 35kD native form of Fas and a 29kD cleaved Fas fragment. Species Crossreactivity: mouse, human and rat

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