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FAS (CD95) (TNF Receptor Superfamily, Member 6)

FAS (CD95) (TNF Receptor Superfamily, Member 6)

Cat no: F0019-61R

Supplier: United States Biological
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.1-0.3ug/ml detects a ~37kD band observed in lysates of cell line MOLT4 (calculated MW of 37.7kD according to NP_000034.1) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F0019-61R
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: tumor necrosis factor receptor superfamily, member 6, tumor necrosis factor receptor superfamily member 6, apoptosis antigen 1, OTTHUMP00000059646, OTTHUMP00000020051, OTTHUMP00000020046, OTTHUMP00000020045, Fas antigen, Fas AMA, CD95 antigen, APO-1 cell surface antigen, TNFRSF6, FASTM, FAS1, CD95, APT1, APO-1, ALPS1A, Fas (TNF receptor superfamily, member 6), FAS
References: 1.Blomberg J, Ruuth K, Jacobsson M, H
Additional info: Recognizes human FAS. Expected to recognize reported isoforms 1 (NP_000034.1), 2 (NP_690610.1) and 3 (NP_690611.1).

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