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FAS Inhibitor, C75 (Trans-4-carboxy-5-octyl-3-methylene-butyrolactone)

Cat no: F0019-64B


Supplier: United States Biological
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Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO, dichloromethane or methanol. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light.
Catalogue number: F0019-64B
Size: 1mg
Form: Supplied as a lyophilized powder. Soluble in DMSO, dichloromethane or methanol.
Purity: ~98%
Alternative names: [Trans-4-carboxy-5-octyl-3-methylene-butyrolactone]

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