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Fatty Acid Amide Hydrolase (FAAH, FAAH-1, MGC102823, MGC138146)

Fatty Acid Amide Hydrolase (FAAH, FAAH-1, MGC102823, MGC138146)

Cat no: F0019-68F2

Supplier: United States Biological
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Endogenous cannabinoids have been implicated in addictive behaviors and drug abuse (1). Fatty-acid amide hydrolase 1 (FAAH1) is a plasma membrane-bound hydrolase that converts oleamide to oleic acid (2). This hydrolase also converts the cannabinoid anandamide, the endogenous ligand for the CB1 cannabinoid receptor, to arachidonic acid, suggesting a role in fatty-acid amide in-activation (2). Mice lacking FAAH1 have significantly higher levels of anandamide in the brain and show decreased sensitivity to pain, further indicating a role for FAAH1 in the regulation of endocannabinoid signaling in vivo (3). FAAH1 null mice also demonstrate an increased preference for alcohol and an increased voluntary uptake of alcohol as compared to wild-type mice, indicating a role of FAAH1 in modulating addictive behaviors (1). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight. Immunoprecipitation: 1:50. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F0019-68F2
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied in 10 mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol, 0.02% sodium azide.
P type: Mab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Blednov, Y.A. et al. (2007) Neuropsychopharmacology 32, 1570-82, 2. Cravatt, B.F. et al. (1996) Nature 384, 83-7, 3.Cravatt, B.F. et al. (2001) Proc Natl Acad Sci USA 98, 9371-6.
Additional info: Recognizes mouse FAAH1. Species crossreactivity: rat.

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