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FBXO31, F-box protein 31

FBXO31, F-box protein 31

Cat no: F0023-86

Supplier: United States Biological
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Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.3-1ug/ml ~75kD band observed in lysates of cell line KELLY (calculated MW of 60.7kD according to NP_079011.3). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Kumar et al, Cancer Res. 2005 Dec 15;65(24):11304-13; PMID: 16357137). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F0023-86
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: putative breast cancer tumor-suppressor, SCF ubiquitin ligase specificity factor, F-box only protein 31, pp2386, MGC9527, MGC15419, Fbx31, FLJ22477, FBXO14, FBX14, DKFZp434J1815, DKFZp434B027, F-box protein 31, FBXO31
References: 1. Kumar R, Neilsen PM, Crawford J, McKirdy R, Lee J, Powell JA, Saif Z, Martin JM, Lombaerts M, Cornelisse CJ, Cleton-Jansen AM, Callen DF, FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. Cancer research 2005 Dec 65 (24): 11304-13.
Additional info: Recognizes human FBXO31. Species sequence homology: mouse, rat, canine, bovine.

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