RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
Biological Activity:
Induces osteoclastogenesis of bone marrow-derived macrophages.
Sequence:
Mouse RANKL (aa 157-316) is fused to at the N-terminus to the Fc portion of human IgG1.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Stable for at least 6 months after receipt when stored at -20 degrees C.
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