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Ferulenol (2-Hydroxy-3-chromen-4-one)

Cat no: 044790


Supplier: United States Biological
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Prenylated 4-hydroxycoumarin. Anti-tumor compound. Cytotoxic. Stimulator of tubulin polymerisation in vitro. Inhibitor of colchicine binding to tubulin. Antitubercular antibiotic with potent antibacterial activity. Anti-coagulant, pro-haemorrhagic compound with higher activity than warfarin. Shows hepatocyte toxicity. Disrupts mitochondrial membrane potential. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C.
Catalogue number: 044790
Size: 1mg
Purity: >98% (HPLC)
Alternative names: 2-Hydroxy-3-chromen-4-one
References: Product Reference: ?Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) ?Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) ?Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis): G. Appendino, et al.; J. Nat. Prod. 67, 210 (2004) ?Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) ?Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle: M. Lahouel, et al.; BBRC 355, 252 (2007) ?Disruption of mitochondrial membrane potential by ferulenol and restoration by propolis extract: antiapoptotic role of propolis: B.H. Nadia, et al.; Acta Biol. Hung. 60, 385 (2009) ?

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