FGF-17, Recombinant, Human (Fibroblast Growth Factor-17, FGFH)

FGF-17 is a heparin binding growth factor that is a member of the FGF family.Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.FGF-17 signals through the FGFR 1c, 2c, 3c, and 4.FGF-17 signals induction and patterning of embryonic brain.Recombinant human FGF-17 is a 22.7kD protein consisting of 195 amino acid residues.\n\nBiological Activity:\nAssay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ~0.5ng/ml, corresponding to a specific activity of ~2x10e6 units/mg.\nAssay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ~10ng/ml, corresponding to a specific activity of ~1x10e5 units/mg.\n\nAA Sequence:\nMTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT\n\nCrossreactivity:\nMouse\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

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