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FGF-23 (R179Q Mutant), Recombinant, Human (His) (Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor)

FGF-23 (R179Q Mutant), Recombinant, Human (His) (Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor)

Cat no: 044809

Supplier: United States Biological
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FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC). The R179Q mutant is resistant to degradation by the endopeptidase PHEX. Biological Activity: Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Sequence: Signal peptide and human FGF-23 (aa 1-251) are fused at the C-terminus to a His-tag. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 044809
Size: 10ug
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Purity: >90% (SDS-PAGE)
Alternative names: Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor

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