FGF-4, Recombinant, Human (Fibroblast Growth Factor 4, KS3, HBGF-4, HST-1)

Fibroblast Growth Factor 4 (FGF-4) is a growth factor predominantly expressed during embryonic development, playing a key role in limb development. In culture, FGF-4 has been shown to be an important regulator of growth for stem cells, fibroblasts and endothelial cells. Unglycosylated FGF-4 is N-terminally cleaved into 13 kDa or 15 kDa proteins that are more active than the precursor 19 kDa protein, Bellosa P, et al. (1993). Human FGF-4 shares high homology and cross- reactivity with the mouse protein.\n\nSource:\nRecombinant protein corresponding to 140aa from human FGF-4 expressed in E.coli. \n\nMolecular Weight: \n~15kD\n\nEndotoxin:\n(same/less than)1EU/ug (LAL) \n\nBiological Activity:\nThe activity is determined by its ability to induce the proliferation of mouse NR6R-3T3 fibroblasts and is typically 0.25-1.25ng/ml.\n\nAA Sequence:\nAAVQSGAGDY LLGIKRLRRL YCNVGIGFHL QALPDGRIGG AHADTRDSLL ELSPVERGVV SIFGVASRFF VAMSSKGKLY GSPFFTDECT FKEILLPNNY NAYESYKYPG MFIALSKNGK TKKGNRVSPT MKVTHFLPRL\n \nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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