Home  >  Products  >  FHL1 (Four and a Half LIM Domains 1, FHL-1, FHL1A, FHL1B, FLH1A, bA535K18.1, KyoT, LIM Protein SLIMMER, MGC111107, RBP Associated Molecule 14-1, RAM14-1, Skeletal Muscle LIM Protein 1, SLIM1, SLIM-1, SLIM, XMPMA)
FHL1 (Four and a Half LIM Domains 1, FHL-1, FHL1A, FHL1B, FLH1A, bA535K18.1, KyoT, LIM Protein SLIMMER, MGC111107, RBP Associated Molecule 14-1, RAM14-1, Skeletal Muscle LIM Protein 1, SLIM1, SLIM-1, SLIM, XMPMA)

FHL1 (Four and a Half LIM Domains 1, FHL-1, FHL1A, FHL1B, FLH1A, bA535K18.1, KyoT, LIM Protein SLIMMER, MGC111107, RBP Associated Molecule 14-1, RAM14-1, Skeletal Muscle LIM Protein 1, SLIM1, SLIM-1, SLIM, XMPMA)

Cat no: F4149-77E1

Supplier: United States Biological
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FHL1 is a 36kD member of the four-and-a half class of the LIM domain-only protein family. It is highly expressed in myocardium and skeletal muscle, and is now known to bind NFATc1, promoting muscle hypertrophy. It is also noted to be a RIP140 binding partner that inhibits estrogen receptor signaling. Human FHL1 is 323aa in length. It contains one C4-type Zn-finger region (aa7-31), three distinct LIM domains (aa40-77; 101-158; 162-212) and a bipartite NLS (aa231-246). There is one 32kD splice variant that shows a 50 aa substitution for aa231-323. This creates a fourth LIM domain. There are also alternative start sites aa29-16 upstream of the standard site, a deletion of aa168-296, and an 11 aa substitution for aa81-91. Over aa93-166, human FHL1 is 97aa identical to mouse FHL1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F4149-77E1
Reactivities: Human
Hosts: Goat
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, Trehalose. Reconstitute with sterile PBS to 200ug/ml.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human FHL1. Species sequence homology: recombinant human FHL2 and rhFHL3 (1%).

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