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FHL2 (Four and a Half LIM Domains 2, DRAL, SLIM3)

Cat no: F4149-78E

FHL2 (Four and a Half LIM Domains 2, DRAL, SLIM3)

Five proteins share the same structural organization and a high degree of sequence homology in this group: four and a half LIM domain protein (FHL) 1, FHL2, FHL3, FHL4, and activator of cAMP-responsive element (CRE) modulator (CREM) in testis (ACT). LIM domains are constituted by a conserved cysteine- and histidine-rich structure shaped in two repeated zinc fingers first identified in the proteins encoded by the Lin-11, Isl-1, and Mec-3 genes. The LIM domain has been shown to function as a protein

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SPECIFICATIONS

Catalog Number

F4149-78E

Size

100ug

Applications

IF, IHC, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Samson, T et al; The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. J Biol Chem 2004, 279: 28641 2. Martin, B et al; The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse \nmyoblasts. J Cell Biol 2002, 159: 113

Additional Info

Recognizes the LIM-only protein FHL2. F4B2-B11 recognizes the N-terminal Zn-Finger motif, it does not crossreact in Western Blotting with the FHL1 and FHL3 proteins. Species crossreactivity: mouse, rat

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