Fibrinogen (Coagulation Factor I)

Fibrinogen (clotting factor I) is a heat labile beta glycoprotein present in plasma. It is the \nprecursor of fibrin, which is the key protein constituting the network of the blood clot. \nThrombin converts fibrinogen to fibrin by limited proteolysis. Fibrin monomers \npolymerize to fibrin which is stabilized by cross-linking.\n\nApplications:\nSuitable for use in IEP and RID. Other applications have not been tested. \n\nRecommended Dilutions: \nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F4199-92L

Size

1ml

Hosts

Rabbit

Form

Supplied as a lyophilized powder. No prevervatives added. Reconstitute with 1ml streil ddH2O. Dilute further with PBS.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Recognizes canine Fibrogen. In immunoelectrophoresis and radial immunodiffusion (Ouchterlony), using various antiserum concentrations against normal dog plasma a single precipitin line is obtained which shows a reaction of identity with the precipitin line obtained with purified fibrinogen. No reaction is obtained with any other plasma protein component or serum. However, the antiserum may also react with fibrin monomers, circulating fibrinopeptides and fibrin degradation products. The antiserum does not cross react with any other component of dog plasma. Inter- species cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants.