Home  >  Products  >  Fibroblast Growth Factor 23 (FGF23, ADHR, HPDR2, Tumor-derived Hypophosphatemia Inducing Factor, HYPF, PHPTC, UNQ3027, PRO9828)
Fibroblast Growth Factor 23 (FGF23, ADHR, HPDR2, Tumor-derived Hypophosphatemia Inducing Factor, HYPF, PHPTC, UNQ3027, PRO9828)

Fibroblast Growth Factor 23 (FGF23, ADHR, HPDR2, Tumor-derived Hypophosphatemia Inducing Factor, HYPF, PHPTC, UNQ3027, PRO9828)

Cat no: F4212-94J

Supplier: United States Biological
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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F4212-94J
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Saito H, Kusano K, Kinosaki M, Ito H, Hirata M, Segawa H, Miyamoto K, Fukushima N. Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. J Biol Chem. 2003 Jan 24;278(4):2206-11. Epub 2002 Nov 4. PMID: 12419819
Additional info: Species Crossreactivity: Human. Other species not tested.

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