Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride)

Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis.\n\nSolubility:\nSoluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water. Up to 25ul of a solution of 13.8mg/ml (40mM) F4513-40 in 100% DMSO can be diluted into 5ml of plain water without precipitation, giving a final concentration of 200uM. In contrast, even a 1:1000 dilution of the same 13.8mg/ml DMSO stock solution into 10mM PBS, pH 7 results in a precipitate. Thus, F4513-40 solubility in PBS is likely to be well below 100uM, perhaps as low as 1-10ug/ml. Either DMSO, ethanol or plain water should be used as the solvent until the final dilution is made into culture medium\n\nElemental Analysis:\nCalculated: \nC=66.35%\nH=9.96%\nCl=10.31%\nN=4.07%\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F4513-40

Size

50mg

Form

Supplied as a white powder

Purity

~98%

References

1. Chiba, K., et al. \"Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus.\" Cell Mol. Immunol. 3:11-19 (2006). 3. Dev, K.K., et al. \"Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis.\" Pharmacol. Ther. 117:77-93 (2008). 3. Kunzendorf, U., et al. \"FTY720