FK-506 (Fujimycin, Tacrolimus)

FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction.\n\nSolubility:\nSoluble in DMSO at 100mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.\n\nMelting Point:\n122-126C\n\nElemental Analysis:\nCalculated:\nC: 64.57%\nH: 8.69%\nN: 1.71%\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. Stable for 12 month. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F4522-01

Size

50mg

Form

Supplied as a white powder.

Purity

~99%

References

1. McCall, E., et al. \"Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes.\" Circ. Res. 79:1110-1121 (1996). 2. Rokaw, M.D., et al. \"FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells.\" Am. J. Physiol. 271:C194-202 (1996). 3. Rokaw, M.D., et al. \"Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells.\" J. Biol. Chem. 271:32468-32473 (1996). 4. Dumont, F.J. \"FK506, an immunosuppressant targeting calcineurin function.\" Curr. Med. Chem. 7:731-748 (2000).