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FK-506 (Fujimycin, Tacrolimus)

Cat no: F4522-02

FK-506 (Fujimycin, Tacrolimus)

FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nSp2/0 myeloma cells with spleen cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F4522-02

Size

200ug

Applications

ELISA

Hosts

Mouse

Form

Supplied as liquid TBS, 0.09% sodium azide.

P Type

Mab

Purity

Purified

Isotype

IgM

References

1. Letko, E. et al. (1999) Tacrolimus (FK 506). Ann. Allergy Asthma Immunol. 83: 179-189.

Additional Info

Recognizes FK-506.

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