Home  >  Products  >  FK506 Binding Protein 135 (FKBP-135, C430014M02Rik, FKBO133, FKBP133, KIAA0674, mKIAA0674, Peptidyl Prolyl Cis Trans Isomerase, RIKEN cDNA C430014M02 gene, RP23 64F17.7)
FK506 Binding Protein 135 (FKBP-135, C430014M02Rik, FKBO133, FKBP133, KIAA0674, mKIAA0674, Peptidyl Prolyl Cis Trans Isomerase, RIKEN cDNA C430014M02 gene, RP23 64F17.7)

FK506 Binding Protein 135 (FKBP-135, C430014M02Rik, FKBO133, FKBP133, KIAA0674, mKIAA0674, Peptidyl Prolyl Cis Trans Isomerase, RIKEN cDNA C430014M02 gene, RP23 64F17.7)

Cat no: F4150-44

Supplier: United States Biological
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Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: F4150-44
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: As reported
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: This antibody is specific for human FKBP-135. Species Crossreactivity: Reacts with human FKBP-135. Other species have not been tested. Reactivity with mouse is unlikely owing to divergence between this ortholog and human FKBP-135 at the site to which the epitope maps.

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