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FK506 binding protein 6, aa1-327, Recombinant, Human (FKBP6, 36kD FKBP, FK506-binding protein 6, FKBP36, FKBP-36, FKBP-6, Immunophilin FKBP36, MGC87179, Peptidyl-prolyl cis-trans isomerase FKBP6, PPIase, PPIase FKBP6, Rotamase)

Cat no: F4150-18M

FK506 binding protein 6, aa1-327, Recombinant, Human (FKBP6, 36kD FKBP, FK506-binding protein 6, FKBP36, FKBP-36, FKBP-6, Immunophilin FKBP36, MGC87179, Peptidyl-prolyl cis-trans isomerase FKBP6, PPIase, PPIase FKBP6, Rotamase)

FK506 binding protein 6, also known as FKBP6, is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Ubiquitously expressed in all tissues, FKBP6 is present at highest levels in testis, liver, kidney, skeletal muscle and heart. Deletion of FKBP6 may contribute to hypercalcemia and growth delay in Williams-Beuren syndrome. \n\nSource:\nRecombinant corresponding to aa1-327 of human FKBP6 6x his tagged expressed in E.coli. \n\nAA Sequences: \nMGSSHHHHHH SSGLVPRGSH MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL VAPDASVLVK YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL SMRRGELARF LFKPNYAYGT LGCPPLIPPN TTVLFEIELL DFLDCAESDK FCALSAEQQD \nQFPLQKVLKV AATEREFGNY LFRQNRFYDA KVRYKRALLL LRRRSAPPEE QHLVEAAKLP VLLNLSFTYL KLDRPTIALC YGEQALIIDQ KNAKALFRCG QACLLLTEYQ KARDFLVRAQ KEQPFNHDIN NELKKLASCY RDYVDKEKEM WHRMFAPCGD GSTAGES\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F4150-18M

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM DTT, 40% glycerol, 1mM EDTA, 50mM sodium chloride.

Purity

~95% (SDS-PAGE)

References

1. Crackower MA., et al. (2003) Science. 300(5623):1231-5. 2. Metcalfe K., et al. (2005) Clin Dysmorphpl. 14(2): 61-5.

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