FKBP1B, Recombinant, Human, aa1-108, His-tag (Peptidyl-prolyl Cis-trans Isomerase FKBP1B, PPIase FKBP1B, 12.6kD FK506-binding Protein, 12.6kD FKBP, FKBP-12.6, FK506-binding Protein 1B, FKBP-1B, Immunophilin FKBP12.6, Rotamase, h-FKBP-12, FKBP12.6, FKBP1L,

FKBP1B, is a member of the immunophilin protein family which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle.\n\nSource:\nRecombinant corresponding to aa1-108 from human FKBP1B, fused to His-tag at N-terminal expressed in E.coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE\n\nMolecular Weight:\n~14.2kD (MALDI-TOF)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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