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FKHRL1 (Forkhead Box Protein O3, AF6q21 Protein, Forkhead in Rhabdomyosarcoma-like 1, FOXO3, FOXO3A)

FKHRL1 (Forkhead Box Protein O3, AF6q21 Protein, Forkhead in Rhabdomyosarcoma-like 1, FOXO3, FOXO3A)

Cat no: F4523-10B

Supplier: United States Biological
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FOXO3A belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOXO3A is an embryonic transcriptional regulator involved in erythropoiesis and plays an important role in the cell cycle of megakaryocytic cells. It also has a critical role in regulation of proliferation, control of oxidative stress and triggers apoptosis by inducing the expression of genes such as the Fas ligand gene TNFSF6. It is also known to regulate cardiac myocyte size downstream of AKT signaling. FOXO3A promotes DNA repair under low stress conditions and a program of cell death under higher level of stress thus protecting quiescent cells from oxidative stress. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-4ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F4523-10B
Reactivities: Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Brunet, A. et al. Science. 303:2011-2015 (2004). 2. Kops, GJPL. et al. Nature. 419:316-321 (2002). 3. Skurk, C. et al. J. Biol. Chem. 280:20814-20823 (2005).
Additional info: Recognizes human FKHRL1. Species Crossreactivity: chicken, bovine, canine, monkey, mouse, rat. Species sequence homology: xenopus.

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