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FLI1 (Friend Leukemia Virus Integration 1 Transcription Factor, Transcription Factor ERGB, Proto-oncogene FLI-1)

Cat no: F6230-10D

FLI1 (Friend Leukemia Virus Integration 1 Transcription Factor, Transcription Factor ERGB, Proto-oncogene FLI-1)

FLI1 is a member of ETS family of transcription factors and is a proto-oncogene involved in erythroleukemia and Ewings sarcoma. FLI1 was originally identified as a common proviral insertion (Friend leukemia insertion site 1) and found in 75% of erythroleukemia cell clones induced by the Friend mouse leukemia virus. A chromosomal translocation between the FLI1 gene and EWS gene is found in most Ewing sarcomas. FLI1 has anti-apoptotic acivities and also interferes with nuclear hormone receptors.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F6230-10D

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum, Rat

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified.

Isotype

IgG2a,k

Additional Info

Recognizes human FLI1. Species Crossreactivity: rat.

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