Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy- labd-14-ene-11-one, Coleonol, Colforsin)

Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, that works as an activator of adenylate cyclase resulting in an increase in the intracellular concentration of cAMP.\n\nSolubility:\nSoluble in DMSO (5mg/ml) or ethanol (6mg/ml).\n\nMelting Point:\n226-229C\n\nElemental Analysis:\nCalculated: C=64.37%, \nH=8.35%\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

F6024-02

Size

50mg

Form

Supplied as a white crystalline powder.

Purity

~99%

References

1. Laurenza, A., et al. \"Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?\" Trends Pharm. Sci. 10:442-447 (1989). 2. Barber, R. and Goka, T.J. \"Adenylate cyclase activity as a function of forskolin concentration.\" J. Cyclic Nucleotide Protein Phosphor. Res. 10:23-29 (1985). 3. Abe, A. and Karaki, H.J. \"Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle.\" J. Pharmacol. Exp. Ther. 249:895-900 (1989). 4. Joost, H.G. and Steinfelder, H.J. \"Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter.\" Mol. Pharmacol. 31:279 (1987). 5. Martin, G.E., et al. \"Forskolin specifically inhibits the bacterial galactose-H+ transport protein, GalP.\" J. Biol. Chem. 269:24870-24877 (1994). 6. Siddhanti, S.R., et al. \"Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts.\" Endocrinology. 136:4834-4841 (1995).