FOXP2, CT (FOXP2, CAGH44, TNRC10, Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein) (Biotin)

FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.\n\nApplications:\nSuitable for use in Western Blot, Immunofluorescence, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunofluorescence 1:10-50\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

035753-Biotin

Size

200ul

Applications

ELISA, IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Lai, C.S., et al. Nature 413(6855):519-523(2001) Lai, C.S., et al. Am. J. Hum. Genet. 67(2):357-368(2000) Margolis, R.L., et al. Hum. Genet. 100(1):114-122(1997) Hurst, J.A., et al. Dev Med Child Neurol 32(4):352-355(1990)

Additional Info

Human, mouse

Alternative Names

FOXP2, CAGH44, TNRC10, Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein