Fractalkine, Recombinant, Human (FKN, A-152E5.2, ABCD-3, Chemokine (C-X3-C Motif) Ligand 1, C-X3-C Motif Chemokine 1, C3Xkine, CXC3, CXC3C, CX3CL1, Neurotactin, NTN, NTT, Small Inducible Cytokine D1, SCYD1)

AHP453B is specific for human fractalkine, otherwise known as CX3CL1, a 397aa CX3C chemokine which signals through the CX3CR1 receptor and is expressed by various tissues including the brain, testis, lung, heart, kidney, colon and skeletal muscle.\n\nAdhesion of fractalkine to the CX3CR1 receptor triggers the chemotaxis and adhesion of leukocytes, including T cells, monocytes and NK cells and studies have suggested that fractalkine is involved in the regulation of brain microglia during neuroinflammatory processes (1) and may play a role in dendritic cell

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SPECIFICATIONS

Catalog Number

F6069-95H

Size

20ug

Form

Supplied as a lyophilized powder in PBS. Preservative free. Reconstitute with sterile PBS to 1mg/ml containing 0.1% BSA.

Purity

Purified by immunoaffinity chromatography.

References

1. Sunnemark, D. et al. (2005) CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental immune encephalomyelitis: kinetics and cellular origin. J. Neuroinflamm. 2: 17. 2. Kikuchi, T. et al. (2005) Involvement of Fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect. Immun. 73: 5350-5357.

Alternative Names

CX3C Membrane-anchored Chemokine, Small Inducible Cytokine Subfamily D Member 1