Free Beta Chorionic Gonadotropin (hCGbeta) BioAssay(TM) ECL Kit (Human)

Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone normally produced by placenta during pregnancy. The hormone is present in blood and urine around seven to thirteen days following implantation of the fertilized ovum. Structurally intact hCG molecules consist of two non-covalently linked polypeptide subunits, the alpha and beta chain subunits. Measurement of intact hCG and of the alpha subunit of hCG appears to give similar results in blood and urine but not the levels of beta subunit. In the normal second-trimester maternal sera, the level of intact hCG range from 20,000 mIU/ml to 50,000 mIU/ml. In contrast, the levels of either free ?- or free ?-hCG are on average one half of 1% of hCG levels. hCG and the free subunits appear not to be useful as serological markers for nontrophoblastic tumors; however, the absolute increase of ?-hCG level in choriocarcinoma patients clearly differentiates it from normal pregnancy.\nRecent studies showed a significant increase in the level of free ?-hCG subunit in trisomy 21 cases as compared with controls. Hence, it has been suggested that free ?-hCG subunit assay in a combination of maternal serum AFP could be effective in a screening protocol for trisomy 21.\n\nIntended Use:\nThe free beta hCG-subunit quantitative assay is designed for in vitro quantitative measurement of human chorionic gonadotropin free beta-subunit in patient

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SPECIFICATIONS

Catalog Number

167552

Size

96Tests

Applications

ELISA

References

1.Brizot ML, Jauniaux E, Mckie AT, Farzaneh F, and Nicolaides KH. Hum Reprod 1995; 10: 2506-9 2.Forest JC, Masse J, Rousseau F, Moutquin JM, Brideau NA, and Belanger M. Clin Biochem 1995; 28: 443-9 3.Breimer L. Ann Clin Biochem 1995: 32: 233 4.Loncar K, Barnabei VM, and Larsen JW Jr. Obstet Gynecol Surv 1995; 50: 316-20 5.Densem J, and Wald NJ. Prenat Diagn 1995; 15: 94-5 6.Ozturk M, Berkowitz R, Goldstein D, Bellet D, Wands JR. Am J Obstet Gynecol 1988; 158:193-8 7.Wald NJ, Cuckle HS, Densem JW, et al. Br. Med J 1988; 297:883-7 8.Hay DL. Br. J Obstet Gynaecol 1988; 95:1268-75 9.Macri JN, et al. Am J Obstet Gynecol 1990; 163:1248-53 10. Ozturk M et al. Endocrinology 1987; 120:499-508 11. Cole LA, et al. Endocrinology 1983; 113:1176 12. Gaspard UJ et al. Clin Endocrinol (OXF) 1980;13:319