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FTY720 Hydrochloride

Cat no: 012651

FTY720 Hydrochloride

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).\n\nForm:\nWhite Solid\n\nMelting Point:\n102-107 degrees C\n\n\nSolubility:\nDMSO, Ethanol, Methanol

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SPECIFICATIONS

Catalog Number

012651

Size

100mg

Form

White Solid

References

Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),

Alternative Names

2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol Hydrochloride; Fingolimod Hydrochloride;

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