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FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, BAR, HRR-1, Nuclear Receptor Subfamily 1 Group H Member 4, NR1H4, Retinoid X Receptor-interacting Protein 14, RXR-interacting Protein 14, RIP14)

Cat no: F9300-02

FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, BAR, HRR-1, Nuclear Receptor Subfamily 1 Group H Member 4, NR1H4, Retinoid X Receptor-interacting Protein 14, RXR-interacting Protein 14, RIP14)

The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed "orphan receptors" because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F9300-02

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in Tris-glycine, 150mM sodium chloride,, pH 7.2, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Species Crossreactivity: Human. Other species have not been tested.

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