FXR (Farnesoid X-activated Receptor, HRR-1, BAR, RIP14, NR1H4)

Farnesoid X-activated receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of the orphan nuclear receptor family. FXR is expressed in the liver, intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and IBABP (ileal bile acid binding protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR. FXR is shown to be transcriptionally activated by farnesol metabolites such as farnesol itself and juvenile hormone III. FXR binds to DNA only as a heterodimer with RXR.\n\nApplications: \nSuitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nDirect ELISA: 0.2ug/ml \nWestern Blot: 1ug/ml\nImmunohistochemistry: 20-40ug/ml \nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nSpleen cells of a BALB/c mouse immunized with recombinant human FXR and mouse myeloma cells (NS-1).\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts