Fyn, active (Src Family Tyrosine Kinase) Recombinant

Fyn is a member of the Src family of non-receptor protein tyrosine kinases and is is highly expressed in brain. Fyn has been shown to be involved in T cell and B cell activation and keratinocyte differentiation. Fyn can regulate the activation of PI-3 kinase in CTLL-2 cells, a murine interleukin 2 responsive cell line. In T cells, Fyn associates with the T cell antigen receptor and Thy-1. A study of human T-cells revealed that Lck and Fyn had different intracellular locations, suggesting that these two members of the Src family regulate different aspects of T cell activation. The Src homology 3 (SH3) region of Fyn can bind the proline-rich domain of the Fas ligand. In addition, Raf-1 may form a complex with Fyn through its Src Homology 2 (SH2) domain and serine phosphorylation of Raf-1.\n\nRecombinant full-length human Fyn with a His-tag expressed in Sf21 cells. Mr: 60kD. \n\nFyn Kinase Assay: ~1.7mU-1.7U phosphorylates the Src substrate peptide in vitro.\n\nStorage and Stability: Stable for 6 months at-70 degrees C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated thawing and freezing.

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