Fyn, p59 (Src Family Tyrosine Kinase)

p59fyn is a membrane-associated nonreceptor protein tyrosine kinase that belongs to the Src-family of kinases. The unique N-terminal domain of p59fyn interacts with the CD3 and Z chains of the TcR. p59fyn can bind other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of fyn activity. p59fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.\n\nEpitope: aa26-75\n\nApplications:\nKinase Assay (Not verified)\nWestern Blot (Not verified)\nImmunohistology (Formalin/paraffin): (Ab 1-2ug/ml for 30 min at RT) Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.\n\nPositive Control: Jurkat cells. Lymphoma.\n\nCellular Localization: Cytoplasmic.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C or colder. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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